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A Clarifying Force

Discover ZO's new powerful yet gentle serum for a continually clear and balanced complexion.

Complexion Clarifying Serum

A water-based serum engineered with ZO® sebum-targeting science, clinically proven to reduce surface oil, congestion + visible redness for a continually clear + balanced complexion.

This foundational staple is formulated for a range of skin types, especially combination, oily + blemish-prone skin.

Fragrance- and alcohol-free.

  • Proven to decongest skin + reduce surface shine in 2 weeks.
  • Minimizes excess sebum with daily use, while providing optimal hydration for a range of skin types.
  • Reduces visible redness for a more uniform complexion.
  • Light, water-gel formula layers easily.
  • Complexion Clarifying Serum features a unique dropper that fills automatically for ease of use. It dispenses the appropriate amount of serum to use, which is about a quarter size.

Before + After


Complexion Clarifying Serum  before-after-1


Complexion Clarifying Serum  before-after-1

Week 4

Pore Size + Number

Complexion Clarifying Serum  before-after-3


Complexion Clarifying Serum  before-after-3

Week 6

PROTOCOL: A 6-week independent, third-party clinical evaluation of 43 female subjects to test the efficacy of Complexion Clarifying Serum. Subjects represented females ages 16 to 44 with Fitzpatrick skint types II-IV. Supported with the use of Gentle Cleanser and Broad-Spectrum Sunscreen SPF 50.

Principle Of Skin Health Restoration

Sebum Control

Excess sebum is an inflammatory substance harmful to skin health. Controlling sebum is essential to prevent + treat many skin conditions, and to optimize the effectiveness of your overall protocol.

Sebum is a waxy, oily mixture produced by sebocyte cells in skin's sebaceous glands, whose activity is influenced by androgen hormones. While sebum plays a protective role against water loss + pathogenic invasion, excess sebum is detrimental to skin.

In addition to causing blemishes + large pores, over production of sebum contributes to inflammatory skin diseases including rosacea, melasma and seborrheic dermatitis.

Further, its waxy nature can inhibit the penetration + efficacy of corrective treatments. Minimizing sebum maximizes results of all skin restoration protocols.

New Exclusive ZO® Technology

Multi-Modal Sebum-Minimizing Science

Complexion Clarifying Serum is engineered with a new, ZO® Sebum-Targeting Complex of 3 plant extracts that deliver a clear + balanced complexion without dryness.


Complexion Clarifying Serum is clinically proven to reduce surface sebum, congestion and facial redness in as early as 2 weeks for an ongoing clear + balanced complexion.  

No.  Complexion Clarifying Serum is uniquely formulated with gentle, water-soluble salicylic acid that does not require the presence of drying solvents, such as alcohol, in the formula like traditional salicylic acid-based products. 
In addition, Complexion Clarifying Serum contains an exclusive polysaccharide complex that supports skin’s barrier plus humectants for light hydration. After 6 weeks of use twice daily, 98% of subjects reported that it did not dry their skin.

Complexion Clarifying Serum's water-soluble salicylic acid powerfully decongests skin without the presence of drying or irritating solvents like traditional salicylic acid products. It is shown to be effective at combatting breakout-causing bacteria while being gentle on a range of skin types.  
In addition, the weightless water-gel formula layers seamlessly into any protocol.

Yes. It is fragrance-free as well as alcohol-free.

Complexion Clarifying Serum features a dropper that fills automatically for ease of application.

The foundation to clear, healthy skin is always GSR®.  Starting your protocol with Exfoliating Cleanser, Dual Action Scrub and Acne Treatment Pads will help to ensure a blemish-free, smooth + radiant complexion.  In addition, Complexion Clearing Masque is an excellent bi-weekly treatment to absorb excess surface oil + other pore impurities and to immediately mattify shininess.

Complexion Clarifying Serum should be gentle enough to use in tandem with prescription topical or oral acne medications.  However, please refer to your prescribing physician for full product guidance. 

Used daily, Complexion Clarifying Serum will help improve congestion + ensure an ongoing clear complexion. To treat more moderate to severe breakouts, we suggest referring to a local ZO® physician who can provide a customized treatment plan based on your skin type, specific skin concerns + lifestyle. 

Complexion Clarifying Serum contains an exclusive, plant-derived polysaccaride complex that supports skin's protective barrier + minimizes signs of premature skin aging.  However, to best treat signs of aging, we recommend ZO's advanced Anti-Aging solutions such as:  
- Growth Factor Serum: fine lines + wrinkles
- Firming Serum: laxity + sagging
- Wrinkle + Texture Repair: deeper wrinkles + rough, sun-damaged texture

It is not recommended following ablative or combined ablative + non-ablative laser treatments.  Please refer to your provider for a proper post-treatment skincare.

Complexion Clarifying Serum reduced surface oil + shine, pore size + congestion and facial redness as early as 2 weeks in an independent clinical study.

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